New Insights on How Metals Disrupt Amyloid β-Aggregation and Their Effects on Amyloid-β Cytotoxicity
نویسندگان
چکیده
منابع مشابه
Effect of Metals on Kinetic Pathways of Amyloid-β Aggregation
Metal ions, including copper and zinc, have been implicated in the pathogenesis of Alzheimer's disease through a variety of mechanisms including increased amyloid-β affinity and redox effects. Recent reports have demonstrated that the amyloid-β monomer does not necessarily travel through a definitive intermediary en-route to a stable amyloid fibril structure. Rather, amyloid-β misfolding may fo...
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Alzheimer’s disease (AD) is a severe neurodegenerative disorder characterized by β-amyloid (Aβ) plaques, neurofibrillary tangles, neuronal death, progressive cognitive impairment and memory loss. β-amyloid peptides (Aβ) are major compositions of so-called senile plaques, which are hallmarks of AD and contribute to AD progression. Therefore, it is important to discover therapeutics against Aβ-in...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m010706200